![]() In the case of renal dysfunction, the creatinine clearance by the kidneys is reduced and therefore the creatinine concentration in the blood rises. Using creatinine in this formula, we obtain the creatinine clearance ( C Cr) resembling an eGFR. Ideally X is a substance that is not altered, accumulated or resorbed by the kidneys and which has the same concentration in the plasma and glomular filtrate. Here, U X and P X are the concentrations of substance X in urine and plasma in mg/mL, respectively. The GFR in mL/min can be calculated with the following formula: GFR = ( U X Clinical significanceĬreatinine blood levels often serves as a measure for determining the estimated Glomerular Filtration Rate ( eGFR), which is a measure for renal function. Creatinine is commonly measured in blood and urine. The equilibrium concentration depends somewhat on diet and muscle mass, and therefore on age, sex, race and body build. Creatinine is usually produced at a fairly constant rate so that its equilibrium concentration is fairly constant in healthy individuals. Creatinine is a breakdown product of phospocreatine and is normally excreted through the kidneys. Creatine is produced by liver, kidneys and the pancreas after which it is transported by the blood to other organs such as muscle and brain, where it is phosphorylated to the high-energy compound phosphocreatine involved in the metabolic process of muscle contraction. ![]() Ĭreatinine is the anhydride of its precursor molecule creatine (C 4H 9N 3O 2). ![]() Anhydrous creatinine is a solid substance and generally considered as non-hazardous. The solubility of creatinine in water is 90 mg/ml at 20☌. Creatinine is an organic compound characterized by the chemical formula C 4H 7N 3O with a total molar mass of 113.12 g/mol and a density of 1.09 g/cm 3.
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